While Parkinson causes are diverse...
Both genetic and environmental causes of Parkinsons Disease are well recognized in the medical literature.
1) Environmental toxins lead to Parkinsons:
Studies, both of large groups of people (epidemiological) and experimental studies show that both pesticides and metal toxicity are Parkinson causes.
2) Genomic defects are among Parkinson Disease causes:
Which Parkinson Disease Causes Might Affect You?
When Parkinson causes converge -- either genomic, or environmental factors or both, these lead to abnormalities in the mitochondria of the cells (the energy centers) and there is more "oxidative stress."
While not a Parkinson cure, we can protect better against toxins, and lower inflammation and oxidative stress.
Researchers say that Parkinson causes are "multifactorial". 1
Risk factors that add up as Parkinson Disease causes, are exposure to:
Some or all factors combine in the brain and nervous system and cause:
A combination of factors can converge over a lifetime as Parkinson causes:
Is Parkinson's a Syndrome rather than a specific Disease?
There is evidence that instead of long term chronic exposure, there was likely a more specific "environmental" or toxic event or exposure.
This would have killed some nigral dopaminergic cells, and damaging others. 3
One of the known markers for PD is low glutathione in the substantia nigra - which was also the case for these animals that were given rotenone and iron.
Glutathione is the body's "protective molecule" and is typically depleted in the brains of Parkinsons patients.
Increasing glutathione in the substantia nigra, they found, gave the test animals "dopaminergic neuroprotection" and decreased the damage caused by these toxins.
This molecule can also protect against the eventual toxic effect of the Parkinsons medications which cause dyskinesia or "shaking:"
See: Dyskinesia caused by Parkinsons Medications, Carbidopa, Levodopa (Sinemet)
While Parkinson causes are multiple, researchers have also found what can protect best.
Even for different Parkinson stages and early symptoms of Parkinson, here is what scientists found to be protective against risk factors:
Why add alternative medicine for Parkinsons treatment?
Long term use of anti parkinsonian drugs have a “wearing-off phenomenon.” Not only that, but they cause additional psychomotor and autonomic complications.
"Shakes" are part of this long term effect of the medications!
Researchers are now looking to prevent cell damage, and to protect the cells that make dopamine - to help them re-generate and to keep them healthy.
Many environmental toxins lead to Parkinsons. Pesticides and metals such as iron and manganese are neuro-toxins. These neuro toxins can cause cell death.
So what have they found so far that can help best?
Fortunately, scientists have studied the neuroprotective effects of many substances
Some things may be easy!
So, they asked, is there something in coffee that is neuro-protective? If so, what is it, and how does it work?
Turns out that no, it is not the caffeine!
Researchers at the Kinsmen Laboratory of Neurological Research, University of British Columbia, tested the ingredients in coffee.
How does it work?
They found that the quercetin actually reduced the amount of damage to the DNA, and the fats and proteins in the brain cells. (The SH-SY5Y cells responsible for making dopamine).
So, drink more coffee!!
But protecting your brain is also multi-factoral! You may need a different Parkinson diet and supplements than others.
Unfortunately, it is not as simple as taking a pill! You have to take the pre-cursors, or building blocks.
Best neuro-protective foods and supplements.
You may ask us about:
We hope that you have been inspired for better Parkinson Disease treatments with natural help.
Metals such as iron are usually high in the brains of Parkinsons patients. Iron can be reduced in the body by:
Knowing the causes Parkinson Disease will hopefully help live a fuller and longer life!
1. Int J Mol Sci. Parkinson’s Disease: From Pathogenesis to Pharmacogenomics 2017 Mar; 18(3): 551. Published online 2017
2. Front Neurosci. Neurochemical and Behavior Deficits in Rats with Iron and Rotenone Co-treatmen. 2017 Nov 23;11:657. doi: 10.3389/fnins.2017.00657. eCollection 2017.
3. PARKINSON’S DISEASE: A SYNDROME NOT A DISEASE Issue: BCMJ, vol. 43 , No. 3, April 2001 , Pages 129-132 Clinical Articles By: Donald B. Calne, OC, DM
4. Neurology. Integration of risk factors for Parkinson disease in 2 large longitudinal cohorts. 2018 Apr 11. pii: 10.1212/WNL.0000000000005473. doi:
CNS Neurosci Ther. The neuroprotective effects of caffeine in neurodegenerative diseases. 2017 Apr;23(4):272-290. doi: 10.1111/cns.12684.
Protection against Parkinson causes:
Better Parkinson Prognosis with Natural Treatments?
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