New Hope for ALS: Research Finds Key Molecule in Lou Gehrig’s disease -- ALS
Although treatment for ALS, Lou Gehrigs disease, remains elusive, scientists are nevertheless showing us key factors underlying the disease process of ALS, giving new hope for better management and significantly slowing its progress.
Researchers have identified the following:
1) That "oxidative stress," which causes damage due to "free radicals" ("oxy-radical" formation), has a specific PATTERN found to be characteristic of a number of neurodegenerative disorders, including Lou Gehrig’s disease.
2) That "oxidative stress" causes disease (has a pathogenic role) where motor neurons are vulnerable, and this increased "oxidative stress" is particularly characteristic of Lou Gehrig’s disease.
What is the key molecule?
3) Researchers have consistently found there to be a DEPLETION of a small molecule in the motor neuron, called glutathione, (GSH) and this LACK of GSH is seen to be the “Mechanism of Toxicity."
And indeed, researchers have found that people with ALS, Lou Gehrig’s disease, have low levels of this protective substance.
What do the Experts Say?
According to DR. JIMMY GUTMAN, FACEP, glutathione expert and author of the book, “Glutathione, Your Key to Health:
• “There is no doubt that LOW glutathione -- GSH levels -- accelerate brain cell death and that elevated levels slow the progression of neurodegeneration.
Glutathione is the major naturally-occurring antioxidant in the brain and serves to combat these oxyradicals. Intervention with glutathione-enhancing therapies would be helpful.”
• Not just another antioxidant, glutathione is the body's MOST POWERFUL PROTECTOR and HEALING AGENT, according to Dr. Gutman and the 700,000 medical studies on GSH he refers to.
• Why? Glutathione is key because “It’s the body's 'decision-maker' of oxidant / antioxidant balance" says Dr. Bikul Das, a researcher in molecular biology.
And not only does it protect from free radical damage, but from bacteria, viruses, toxins, pollutants and even cancer.
• BUT BEFORE YOU TAKE a glutathione PILL, which is NOT effective, according to Dr. Gutman, you would be wise to find out exactly how the body makes glutathione, so that YOUR BODY CAN MAKE MORE:
What’s The Best Intervention?
DR. GUTMAN recommends stimulating the body’s own production of glutathione safely and effectively without drugs, so as to promote and restore health -- using nutritional pre-cursors.
Dr. Gutman does NOT suggest taking NAC (except for in a medical emergency) or A GLUTATHIONE PILL, which he says, is USELESS and INEFFECTIVE!
Even IV glutathione, he says, gives "highs" but also undesirable "lows" and is therefore not a good long term strategy.
Get Dr. Gutman's GSH Recommendations:
YOU CAN ASK TO SEE:
• Medical research linking ALS, Lou Gehrig's to lower levels of glutathione & oxidative stress
• Dr. Gutman's references and recommendations for improving your glutathione, GSH in clinically proven ways
Unfortunately, improving GSH, glutathione is NOT simply a matter of eating it in your food, or taking it in a PILL.
Why? Because it is destroyed by the digestion. Even taking IV glutathione has not been found to be effective in the long run, as it deteriorates in the blood before it gets to where it is needed.
Rather, GSH is best made from PRECURSORS by the cell itself, from 3 amino acids: 1) Glycine, 2) Glutamate and 3)Cysteine.
The first two are plentiful in our food, but it turns out that the third, CYSTEINE, is the most difficult to get from our diet.
How to Improve Your Glutathione Levels?
An “accidental finding” led Dr. Gustavo Bounous to determine that it is best done through nutrition by providing the precursors for the body to make its own glutathione.
Dr. Bounous had worked for over 25 years for the Canadian MEDICAL RESEARCH COUNCIL. He was initially looking for a protein that would help people recover from surgery faster.
What he discovered instead, was nutrition that significantly extended the life of his research animals -- THEY LIVED 50% LONGER -- and it protected them from cancer and other diseases, with implications for degenerative conditions like Lou Gehrigs.
He found out what raises glutathione naturally, safely, and effectively, and this was clinically tested with AIDS, cancer, lung disease and other conditions, with implications for diseases like ALS, Lou Gehrigs disease.
Boosting Your GSH for ALS, Lou Gehrig's:
Get a recommendation for clinically proven ways to improve your glutathione GSH, for YOUR situation or diagnosis:
Oxidative Stress, GSH Depletion & ALS
Certainly, damage resulting from “oxidative stress” is part of the aging process, but it has been shown to have a more specific or “targeted” role in neuro-degenerative diseases such as Lou Gehrigs disease.
How? Neurological diseases are particularly characterized by high levels of oxidative stress and free radical formation – oxyradicals -- as well as abnormalities in glutathione metabolism and antioxidant defenses.
• Even mental stress has been shown to destabilize oxidant/antioxidant balance in the brain.
• And indeed, researchers have found that PEOPLE WITH ALS, LOU GEHRIG’S DISEASE HAVE LOW LEVELS OF THIS PROTECTIVE SUBSTANCE.
WHAT IS TYPICALLY KNOWN from the explosion of the field of free radical biology over the past 20 years, is that “oxidative stress” causes damage due to “free radicals” produced by this “stress.”
• BUT WHAT IS LESSER KNOWN is the over 70,000 medical publications that show how a small molecule called glutathione protects the body from free radical damage and the toxic effects of this damage on the cells, including the motor neuron cells.
See Research on Oxidative Stress, GSH and ALS Lou Gehrig’s Disease:
Ask us to send you medical studies about ALS and oxidative stress:
Stopping Neurological Degeneration for ALS
The picture that emerges from medical research is that glutathione’s role is to protect us against the main villains that are at the root of aging and diseases like Lou Gehrigs:
1) free radicals and oxidative stress, 2) an over or under-active immune response 3) toxins and pollutants, and 4) mutations in our DNA.
Scientists have found that:
• That PEOPLE WHO ARE IN EXCELLENT PHYSICAL AND MENTAL HEALTH HAVE HIGH LEVELS OF GLUTATHIONE...
...whereas LOW LEVELS OF GLUTATHIONE HAVE BEEN FOUND AS A MARKER for the major diseases of our time, including the neurodegenerative Alzheimers disease, Parkinsons disease and Lou Gehrigs disease.
• WHY THE PROBLEM? Our glutathione supply is rapidly consumed on a daily basis through normal metabolism, illness and even exercise.
Without a good supply of glutathione, you have an inadequate defense system, and this can eventually lead to illness and to neurodegenerative diseases such as Lou Gehrigs disease.
There are people who have recovered from ALS, Lou Gehrigs disease, and this may be the scientific basis for their recovery!
Links for Neurological Diseases, Parkinsons & Alzheimers
Recent Health Discoveries: Nutrition, Proven Nutraceuticals -- Alternative Medicine for ALS: Lou Gehrig's Disease & Supplements Slowing Neuro Degeneration